The Protective Nature of a Fluoropolymer Stent
Fluoropolymer Safety Resulting from Fluoropassivation
Yet another factor sets XIENCE apart: the XIENCE fluoropolymer coating. Unlike other polymer coatings, the fluoropolymer interacts with proteins in the blood in a way that reduces thrombus formation—a process known as fluoropassivation.
How Fluoropassivation Leads to Thromboresistance
Fluoropolymer Stent vs Bare Metal Stent and Biodegradable Polymer Stent
Moreover, XIENCE's fluoropolymer has minimal coating defects compared to biodegradable polymer drug-eluting stents (BP-DES).11
In contrast to the visual above, most stents available today have non-fluorinated surfaces: biodegradable polymer stents, durable polymer stents or bare metal stents (BMS). These surfaces interact with proteins in the following ways:
- The surfaces attract less albumin and more fibrinogen.3
- The fibrinogen, in turn, leads to more platelet adhesion and activation.12,13
- The platelets, fibrinogen and red blood cells can aggregate and create a thrombus.14,15
CVPath Institute conducted a test to show real time platelet-device interaction between different types of stents.
- Human blood was used to collect blood platelets, which were labeled with fluorescent dye to be visualized under confocal microscopy.
- Devices to be tested were placed in a flow chamber and labeled platelets were circulated at physiological shear rate.
- Real-time platelet-device interaction was visualized under confocal microscopy and recorded in a time-lapse video. Image processing was done to quantify platelet deposition on devices.
Visual Evidence of Fluoropolymer Safety
In several analyses, XIENCE exhibits the most thromboresistance when compared to several different BP-DES.16,17 And this reduced inflammation can lead to improved healing.
Least Thrombus Area with XIENCE vs BP-DES16
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AP2944593-WBO Rev. B