The Protective Nature of a Fluoropolymer Stent
Fluoropolymer Safety Resulting from Fluoropassivation
Yet another factor sets XIENCE apart: the XIENCE fluoropolymer coating. Unlike other polymer coatings, the fluoropolymer interacts with proteins in the blood in a way that reduces thrombus formation—a process known as fluoropassivation.
Fluoropolymer Stent vs Bare Metal Stent and Biodegradable Polymer Stent
Moreover, XIENCE's fluoropolymer has minimal coating defects compared to biodegradable polymer drug-eluting stents (BP-DES).11
In contrast to the visual above, most stents available today have non-fluorinated surfaces: biodegradable polymer stents, durable polymer stents or bare metal stents (BMS). These surfaces interact with proteins in the following ways:
- The surfaces attract less albumin and more fibrinogen.3
- The fibrinogen, in turn, leads to more platelet adhesion and activation.12,13
- The platelets, fibrinogen and red blood cells can aggregate and create a thrombus.14,15
“The thromboresistant properties of XIENCE do not depend fully on better re-endothelialization—since that affects less common late and very late ST. The difference in XIENCE’s rates of ST occurs as early as 30 days, when there is no endothelialization. So it’s the polymer which really has the thromboresistant properties.”
— Tullio Palmerini, MD
Visual Evidence of Fluoropolymer Safety
In several analyses, XIENCE exhibits the most thromboresistance when compared to several different BP-DES.16,17 And this reduced inflammation can lead to improved healing.
Least Thrombus Area with XIENCE vs BP-DES16
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AP2944593-WBO Rev. B