The Science Behind XIENCE

“Patients with complex lesions are no longer the exception, they’re actually the majority. . . . [Now] XIENCE is a solution for complex intervention.”

 Chuck Simonton, MD, Abbott Vascular Chief Medical Officer 

The XIENCE mechanism of action pairs a proven design and delivery system–along with a unique, durable fluoropolymer–for thromboresistance and reduced inflammation. Here's why it's the most implanted stent worldwide.

“A drug-eluting stent consists of three components . . .  a metallic platform, a polymer and a drug, all influencing acute and long-term results both in safety and in efficacy.” 

— Jean Fajadet, MD1 


Unique Design Behind XIENCE Safety Data

All components of the XIENCE stent are designed for safety as well as efficacy.

STENT DESIGN

  • Flexible stent and delivery system offer more conformability to vessel anatomy2 
  • Low metal-to-artery ratio reduces injury and/or inflammation3 
  • Thin struts are designed for rapid healing and reduced thrombogenicity4,5

COATING TECHNOLOGY

  • Fluorinated polymer is associated with thromboresistance6 and minimal inflammation7 
  • Faster endothelialization and more functional endothelium8-10
  • Coating offers durability, flexibility and elasticity11,12

DRUG

  • Everolimus, patented to reduce restenosis 
  • Elution rate matches restenosis cascade by optimal coating thickness
  • Cytostatic
 

Unique Design Behind XIENCE Safety Data

All components of the XIENCE stent are designed for safety as well as efficacy.

STENT DESIGN

  • Flexible stent and delivery system offer more conformability to vessel anatomy2 
  • Low metal-to-artery ratio reduces injury and/or inflammation3 
  • Thin struts are designed for rapid healing and reduced thrombogenicity4,5

COATING TECHNOLOGY

  • Fluorinated polymer is associated with thromboresistance6 and minimal inflammation7 
  • Faster endothelialization and more functional endothelium8-10
  • Coating offers durability, flexibility and elasticity11,12

DRUG

  • Everolimus, patented to reduce restenosis 
  • Elution rate matches restenosis cascade by optimal coating thickness
  • Cytostatic
Experts' Point of View: XIENCE's Fluoropolymer Benefits

"We used to think in the early days of drug-eluting stents . . . that having to add the polymer to control the dose and elution kinetics of the drug was a necessary evil. But I think we're learning here, in terms of thromboresistance, that the [XIENCE] polymer can be a plus."

Gregg Stone, MD

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Just as the stent design is critical to patient outcomes, so is the polymer coating. Hear what physicians have to say about the XIENCE fluoropolymer and its thromboresistance.

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  1. Fajadet J, et al. PLATINUM PLUS. TCT 2012.
  2. Colombo A, et al. JACC. 2002;40:1021-1033.
  3. Data on file at Abbott Vascular.
  4. Kolandaivelu K, et al. Circulation. 2011;123;1400-1409.
  5. Kastrati A, et al. Circulation. 2001;103;2816-2821.
  6. Panchalingam V, et al. ASAIO J. 1993;39:M305-M309.
  7. Paton DM, et al. U.S. Patent 5,356,668.
  8. Ding NI, et al. J Interv Cardiol. 2009;22:S18-S27.
  9. Ao PY, et al. Eur J Vasc Endovasc Surg. 2000;20:241-249.
  10. Joner M, et al. JACC. 2008;52:333-342.
  11. Tu RH, et al. U.S. Patent 4,816,339.
  12. Lo ES. U.S. Patent 3,178,399. 

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