XIENCE Sierra vs. Orsiro

Strut thickness, as with many design considerations of drug-eluting stents (DES), is a balancing act: too thick and critical post-deployment aspects like endothealial coverage or blood flow could be at risk; too thin and mechanical metrics could be affected, such as weaker radial strength, compromised visbility, greater risk of dislodgement, and longitudinal stent deformation6-9. XIENCE balances this important design goal, as shown in acute thrombogenicity performance and clinical safety endpoints1.

Best Stent Retention on the Market2

XIENCE Sierra delivers market-leading stent retention, which is critical in challenging anatomy. Stent retention data6 show that XIENCE Sierra is:

80%

Stronger Than Synergy

150%

Stronger Than Orsiro

199%

Stronger Than Resolute Onyx

Significantly Greater Radial Strength3

The stent design goal of a DES is to balance acute performance with mechanical strength while achieving exceptional pushability, crossability, and flexibility.

Radial Strength Average (mmHg) for 3.0 mm Size
XIENCE Sierra™

1,195

Orsiro™

1,089

Significantly Lower
Radial Strength

1,300

1,250

1,200

1,150

1,100

1,050

1,000

Excellent Radiopacity4

Mechanical strength isn´t the only consideration when treating complex patients. Radiopacity is an important attribute of any DES, and XIENCE Sierra offers better visability compared to Orsiro.

Images taken at magnification 2 with 8 mass in front of beam. Tests performed by and data on file at Abbott.

5-years Randomized Data Shows Significantly Higher All-cause Mortality with Orsiro vs. XIENCE, and Numerically Higher TLF5

Biosicence Trial 5-Year Results



All-Cause Mortality at 5 Years
BIOSCIENCE Trial, n=1537
Orsirio

14.1%

XIENCE

10.3%

P=0.017

Target Lesion Failure

AP2947116-WBU Rev A

  1. XIENCE showed significant benefit compared to several DES and composite BMS in multiple large scale meta-analyses and other RCTs. Source: Palmerini, et al. The Lancet. 379:9824, 14-20 April 2012, pp. 1393-1402; Bangalore S, et al. Circ Cardiovasc Interv, Aug 6, 2013. doi: 10.1161/circinterventions.113.000415; Valgimigli, Effects of Cobal-chromium Everolimus eluting or bare metal stent on fatal and non-fatal cardiovascular events. A patient-level meta analysis. EuroPCR 2014; Serruys, PW, et al. RESOLUTE All Comers Trial, NEJM 2010. Published online June 16, 2010; Fajadet, J., et al. PLATINUM PLUS 30-day Poster, TCT 2012.
  2. Test performed and data on file at Abbott. 3.0 x 18 mm XIENCE Sierra(TM), Orsiro(TM), and Resolute Onyx(TM) texted. 3.0 x 20 mm Synergy(TM) tested. 
  3. Tests performed and data on file at Abbott. Radial data refers to 3.0 mm diameter and 18-20 mm lengths.
  4. Images taken at magnification 2 with 8" mass in front of beam. Tests performed and data on file at Abbott.
  5. Pilgrim T, et al. “Randomized comparison of an ultrathin strut cobalt-chromium biodegradable polymer sirolimus-eluting stent with a thin strut durable polymer everolimus-eluting stent for PCI – Final 5-year outcomes of the BIOSCIENCE trial” ESC 2018.
  6. Kolandaivelu et al.; Circulation 2011; 123; 1400-1409.
  7. Colombo et al.; J Amer Coll Cardiol 2002;40(6): 1021-1033.
  8. ISAR STEREO I, Kastrati et al.; Circulation 2001; 103; 2816-2821.
  9. ISAR STEREO II JACC Vol. 41, No. 8, 2003 April 16, 2003:1283-8.

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