The Proactive Protection of XIENCE Fluoropassivation
The XIENCE Fluoropolymer Stent Coating Promotes Best-in-Class Safety And Healing
In addition to clinical safety, another factor that sets XIENCE apart is the XIENCE fluoropolymer coating. Unlike most other polymers, the fluoropolymer interacts with proteins in the blood in a way that reduces thrombus formation1—a process known as fluoropassivation.
How Fluoropassivation Leads to Low Thrombus and Inflammation
Due to thromboresistance and low inflammatory responses, fluorinated surfaces encourage faster endothelization and healing.1,2
Fluoropolymer Stent vs Bare Metal Stent and Bioabsorbable Polymer Stent
In contrast to the visual above, most stents available today have non-fluorinated surfaces: bioabsorbable polymer stents, durable polymer stents or bare metal stents (BMS). These surfaces interact with proteins in the following ways:
- The surfaces attract less albumin and more fibrinogen.3,5
- The fibrinogen, in turn, leads to more platelet adhesion and activation.9,10
- The platelets, fibrinogen and red blood cells can aggregate and create a thrombus.6,11
CVPath Institute conducted a test to show real time platelet-device interaction between different types of stents.
XIENCE compared with Synergy
XIENCE compared with other competitors
- Human blood was used to collect blood platelets, which were labeled with fluorescent dye to be visualized under confocal microscopy.
- Devices to be tested were placed in a flow chamber and labeled platelets were circulated at physiological shear rate.
- Real-time platelet-device interaction was visualized under confocal microscopy and recorded in a time-lapse video. Image processing was done to quantify platelet deposition on devices.
A Difference You Can See
In several analyses, XIENCE exhibits the most thromboresistance when compared to several different BP-DES.12,13 This thromboresistance, along with reduced inflammation shown by the XIENCE fluoropolymer, may lead to improved healing.
Compare XIENCE stent coating inflammatory response to BP-DES
Expert's Point of View: Reduced Inflammatory Response
In the images “on the right you can see the [pro-thrombotic] platelet adherence. XIENCE [the image at the bottom] has hardly any attachments to it.”
— Renu Virmani, MD, referring to the photomicrographs, where green indicates platelet adhesion
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